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KMID : 0351819860270040375
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Kyunpook University Medical Journal
1986 Volume.27 No. 4 p.375 ~ p.383
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Effect of Panax Ginseng on Digoxin Cardiac Arrhythminas in Rabbits
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배연수
김중영
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Abstract
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This experiment was undertaken to study the effect of ginseng saponin extracted from panax ginseng on electrocardiograpihc changes induced by administration of toxic dose of digoxin. The changes of arterial blood pressure, heart and respiratory rate were also observed. The experimental animals were male rabbits weighing about 2.5㎏ anesthetized with urethane. Ginseng saponin(100, 400 and 800 ㎎/㎏) and digoxin (0.75㎎/㎏) were injected through ear vein. The results are summerized as follows:
In control group, the injection of 800 ㎎/㎏ ginseng saponin did not produce elec trocardiographic changes, but transient lowering of systolic and diastolic blood pressure were observed in early stage after injection with dose of 100, 400 and 800 ㎎/㎏, and also there noted a weak bradycardia with dose of 800 ㎎/㎏, and an increase in respiratory rate with dose of 400 and 800 ㎎/㎏ of ginseng saponin.
In control group, 5 to 20 minutes after the injection of 0.75㎎/㎏ digoxin produced ventricular bigeminy, unifocal premature ventricular contraction, consecutive premature ventricular contraction and sinus bradycardia, and there noted transient lowering of sytolic and diastolic blood pressure in early stage, a slight decrease in heart rate, and a marked increase in respiratory rate.
In experimental group pretreated with dose of 100, 400, and 800 ㎎/㎏ ginseng saponin, 0.75 ㎎/㎏ digoxin had a tendency of producing multifocal premature ventricular contraction, A-V junctional rhythm and ventricular trigeminy, which were not observed in control group. In addition, pretreatment with ginseng saponin increased the incidence of consecutive premature ventricular contraction and sinus bradycardia after injection of digoxin. However, the incidence of ventricular bigeminy was not affected. The appearance time of digoxin-induced cardiac arrhythmias was widely dispersed from 5 to 50 minutes.
In rabbits pretreated with ginseng saponin, the degree of lowering of systolic blood pressure caused by digoxin injection was affected by ginseng saponin administration, but that of diastolic pressure was not affected. The duration of bradycardia induced by digoxin was more prolonged by ginseng saponin pretreatment.
With these results, it is suggested that ginseng saponin has some adverse effects on digoxin-induced cardiac arrhythmias.
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KEYWORD
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Ginseng saponin, Digoxin, Cardiac arrhythmias
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